Main content

Antipsychotics

Use this tool to compare antipsychotics and their side effects

Antipsychotics can cause unpleasant side effects. Each drug differs in this respect. However, there are three effects that apply to all antipsychotics:
  1. Antipsychotic medications make you feel flat and take less initiative, as they dampen your emotions.
  2. The skin can become hypersensitive to sunlight, therefore stay out of excessive sunlight and use sunscreen.
  3. The higher the dose, the higher the risk of side effects.
You cannot predict in advance which drug will work best for you. It's a matter of trial and error. However, the side effects of the various drugs are more predictable - so you can make a choice informed by side effect profile.

Which medications do you want to compare?

Choose your medication

Please note that different countries have registered different antipsychotics.
Therefore, not all antipsychotics available in your country may appear in the list, and
some antipsychotics in the list may not be available in your country.

Make your choice here

Select 2 Antipsychotics

What are antipsychotics?

During a psychosis, you experience the world around you differently. You may hear voices, see things or have paranoia. You also can be confused and feel anxious.

Antipsychotics block the effects of dopamine in the brain. This makes you a little indifferent, also with respect to your psychotic experiences. The antipsychotic also makes you feel calmer, less anxious and able to think clearly again. You also sleep better. The drugs help you to regain control of your life. They also prevent another psychosis from happening.

Up to 3

Select at least 2 antipsychotics.

What are antipsychotics?

During a psychosis, you experience the world around you differently. You may hear voices, see things or have paranoia. You also can be confused and feel anxious.

Antipsychotics block the effects of dopamine in the brain. This makes you a little indifferent, also with respect to your psychotic experiences. The antipsychotic also makes you feel calmer, less anxious and able to think clearly again. You also sleep better. The drugs help you to regain control of your life. They also prevent another psychosis from happening.

You compare

  • Amisulpride (AMI)
  • Aripiprazol (ARI)
  • Brexpiprazol (BRE)
  • Broomperidol (BRO)
  • Cariprazine (CAR)
  • Chloorprotixeen (CHL)
  • Clozapine (CLO)
  • Flupentixol (FLP)
  • Fluspirileen (FLS)
  • Haloperidol (HAL)
  • Lurasidon (LUR)
  • Olanzapine (OLA)
  • Paliperidon (PAL)
  • Penfluridol (PEN)
  • Periciazine (PER)
  • Pimozide (PIM)
  • Pipamperon (PIP)
  • Quetiapine (QUE)
  • Risperidon (RIS)
  • Sertindol (SER)
  • Sulpiride (SUL)
  • Tiapride (TIA)
  • Zuclopentixol (ZUC)
  • High : affects more than 30 in 100 people
  • Moderate : affects 10 to 30 in 100 people
  • Low : affects 1 to 10 in 100 people
  • Very low : affects less than 1 in 100 people
  • No side effects

Amisulpride (AMI)

If you use this medicine, you will sometimes need extra blood tests to measure the prolactin level.

  • Sexual problems

    You have a low sex drive. For men it is more difficult to get an erection and they have less or no sperm. For women it is harder to have an orgasm. Their menstruation is irregular or absent. These symptoms may be related to the hormone prolactin, but it can also be caused by other factors.

  • Increased prolactin level

    Your brain produces too much of the hormone prolactin. This causes sensitive breast tissue and milk discharge from your breasts. This is called galactorrhea and can occur in both women and men. You also have a low sex drive and you can gain weight. Women suffer from menstrual disorders (amenorrhea) and can be less fertile. Breasts can develop in men.

  • ECG alterations (heart rhythm changes)

    You suffer from palpitations of the heart, an irregular heartbeat or a slower or faster heartbeat. You may suddenly become dizzy or pass out for a moment.

Aripiprazol (ARI)

If you use this medicine, you will sometimes need extra checkups to check on the occurrence of restlessness, agitation and insomnia.

  • The urge to move

    You feel restless and you cannot sit or stand still. For example, you constantly twitch your legs or cross and uncross your legs.

  • Insomnia

    You have problems sleeping. This means that you do not fall asleep, lie awake for a long time or often or wake up too early.

Brexpiprazol (BRE)

No Additional issues for this antipsychotic.  
  • The urge to move

    You feel restless and you cannot sit or stand still. For example, you constantly twitch your legs or cross and uncross your legs.

Broomperidol (BRO)

This is an old drug that has been researched less extensively. This means that there is a chance that it has more side effects than listed here.

  • Stiffness of the muscles and trembling

    You have stiff muscles and difficulty with moving, walking or speaking. You may also experience tremors.

  • Muscle cramps and twitches

    You have (sometimes painful) muscle cramps and twitches, especially in your head, neck and hands. It causes unusual body positions and your eyes can turn away.

  • Hypersalivation

    Because it is harder to swallow your saliva, you have too much saliva in your mouth. This is often accompanied by drooling, especially when you are sleeping. Sometimes it is difficult for other people to understand what you are saying.

Cariprazine (CAR)

No Additional issues for this antipsychotic.  
  • The urge to move

    You feel restless and you cannot sit or stand still. For example, you constantly twitch your legs or cross and uncross your legs.

  • Stiffness of the muscles and trembling

    You have stiff muscles and difficulty with moving, walking or speaking. You may also experience tremors.

  • Muscle cramps and twitches

    You have (sometimes painful) muscle cramps and twitches, especially in your head, neck and hands. It causes unusual body positions and your eyes can turn away.

Chloorprotixeen (CHL)

This is an old drug that has been researched less extensively. This means that there is a chance that it has more side effects than listed here.

  • Weight gain

    The medication makes you gain weight, because you no longer feel when you have had enough to eat. Sometimes you can even develop obesity.

  • Sexual problems

    You have a low sex drive. For men it is more difficult to get an erection and they have less or no sperm. For women it is harder to have an orgasm. Their menstruation is irregular or absent. These symptoms may be related to the hormone prolactin, but it can also be caused by other factors.

  • Increased prolactin level

    Your brain produces too much of the hormone prolactin. This causes sensitive breast tissue and milk discharge from your breasts. This is called galactorrhea and can occur in both women and men. You also have a low sex drive and you can gain weight. Women suffer from menstrual disorders (amenorrhea) and can be less fertile. Breasts can develop in men.

Clozapine (CLO)

You only get this medicine if other drugs do not work. If you use this medicine, you will need extra blood tests regularly and also your weight must be checked more often.

  • Drowsiness and sleepiness

    You have a drowsy, sleepy and listless feeling. As a result, you are unable to concentrate. It is also difficult to motivate yourself to exercise, which can cause weight gain.

  • Weight gain

    The medication makes you gain weight, because you no longer feel when you have had enough to eat. Sometimes you can even develop obesity.

  • Dizziness

    You get dizzy when you get up from bed or a chair. This side effect usually disappears within a few days to weeks.

Flupentixol (FLP)

This is an old drug that has been researched less extensively. This means that there is a chance that it has more side effects than listed here.

  • Weight gain

    The medication makes you gain weight, because you no longer feel when you have had enough to eat. Sometimes you can even develop obesity.

  • Sexual problems

    You have a low sex drive. For men it is more difficult to get an erection and they have less or no sperm. For women it is harder to have an orgasm. Their menstruation is irregular or absent. These symptoms may be related to the hormone prolactin, but it can also be caused by other factors.

  • Increased prolactin level

    Your brain produces too much of the hormone prolactin. This causes sensitive breast tissue and milk discharge from your breasts. This is called galactorrhea and can occur in both women and men. You also have a low sex drive and you can gain weight. Women suffer from menstrual disorders (amenorrhea) and can be less fertile. Breasts can develop in men.

Fluspirileen (FLS)

This is an old drug that has been researched less extensively. This means that there is a chance that it has more side effects than listed here.

  • Drowsiness and sleepiness

    You have a drowsy, sleepy and listless feeling. As a result, you are unable to concentrate. It is also difficult to motivate yourself to exercise, which can cause weight gain.

  • Stiffness of the muscles and trembling

    You have stiff muscles and difficulty with moving, walking or speaking. You may also experience tremors.

  • Sexual problems

    You have a low sex drive. For men it is more difficult to get an erection and they have less or no sperm. For women it is harder to have an orgasm. Their menstruation is irregular or absent. These symptoms may be related to the hormone prolactin, but it can also be caused by other factors.

Haloperidol (HAL)

No Additional issues for this antipsychotic.  
  • Sexual problems

    You have a low sex drive. For men it is more difficult to get an erection and they have less or no sperm. For women it is harder to have an orgasm. Their menstruation is irregular or absent. These symptoms may be related to the hormone prolactin, but it can also be caused by other factors.

  • Increased prolactin level

    Your brain produces too much of the hormone prolactin. This causes sensitive breast tissue and milk discharge from your breasts. This is called galactorrhea and can occur in both women and men. You also have a low sex drive and you can gain weight. Women suffer from menstrual disorders (amenorrhea) and can be less fertile. Breasts can develop in men.

  • Stiffness of the muscles and trembling

    You have stiff muscles and difficulty with moving, walking or speaking. You may also experience tremors.

Lurasidon (LUR)

No Additional issues for this antipsychotic.  
  • Drowsiness and sleepiness

    You have a drowsy, sleepy and listless feeling. As a result, you are unable to concentrate. It is also difficult to motivate yourself to exercise, which can cause weight gain.

  • Gastrointestinal symptoms

    You have gastrointestinal symptoms, such as nausea, diarrhea and constipation.

  • Stiffness of the muscles and trembling

    You have stiff muscles and difficulty with moving, walking or speaking. You may also experience tremors.

Olanzapine (OLA)

If you use this medicine, you sometimes will need extra checkups for your weight.

  • Weight gain

    The medication makes you gain weight, because you no longer feel when you have had enough to eat. Sometimes you can even develop obesity.

  • Metabolic syndrome

    The metabolic syndrome is a combination of four symptoms: high blood pressure, diabetes, high cholesterol and obesity. These symptoms increase the risk of cardiovascular diseases.

  • Gastrointestinal symptoms

    You have gastrointestinal symptoms, such as nausea, diarrhea and constipation.

Paliperidon (PAL)

If you use this medicine, you will sometimes need extra blood tests to measure the prolactin level.

  • Sexual problems

    You have a low sex drive. For men it is more difficult to get an erection and they have less or no sperm. For women it is harder to have an orgasm. Their menstruation is irregular or absent. These symptoms may be related to the hormone prolactin, but it can also be caused by other factors.

  • Increased prolactin level

    Your brain produces too much of the hormone prolactin. This causes sensitive breast tissue and milk discharge from your breasts. This is called galactorrhea and can occur in both women and men. You also have a low sex drive and you can gain weight. Women suffer from menstrual disorders (amenorrhea) and can be less fertile. Breasts can develop in men.

  • Dizziness

    You get dizzy when you get up from bed or a chair. This side effect usually disappears within a few days to weeks.

Penfluridol (PEN)

This is an old drug that has been researched less extensively. This means that there is a chance that it has more side effects than listed here.

  • Stiffness of the muscles and trembling

    You have stiff muscles and difficulty with moving, walking or speaking. You may also experience tremors.

  • Sexual problems

    You have a low sex drive. For men it is more difficult to get an erection and they have less or no sperm. For women it is harder to have an orgasm. Their menstruation is irregular or absent. These symptoms may be related to the hormone prolactin, but it can also be caused by other factors.

  • Low blood pressure

    When you stand up from a sitting or lying position, your blood pressure drops. This can make you feel dizzy or nauseous and you may see black spots or stars. You also have more risk of falling.

Periciazine (PER)

This is an old drug that has been researched less extensively. This means that there is a chance that it has more side effects than listed here.

  • Drowsiness and sleepiness

    You have a drowsy, sleepy and listless feeling. As a result, you are unable to concentrate. It is also difficult to motivate yourself to exercise, which can cause weight gain.

  • Dizziness

    You get dizzy when you get up from bed or a chair. This side effect usually disappears within a few days to weeks.

  • Stiffness of the muscles and trembling

    You have stiff muscles and difficulty with moving, walking or speaking. You may also experience tremors.

Pimozide (PIM)

This is an old drug that has been researched less extensively. This means that there is a chance that it has more side effects than listed here.

  • Sexual problems

    You have a low sex drive. For men it is more difficult to get an erection and they have less or no sperm. For women it is harder to have an orgasm. Their menstruation is irregular or absent. These symptoms may be related to the hormone prolactin, but it can also be caused by other factors.

  • Increased prolactin level

    Your brain produces too much of the hormone prolactin. This causes sensitive breast tissue and milk discharge from your breasts. This is called galactorrhea and can occur in both women and men. You also have a low sex drive and you can gain weight. Women suffer from menstrual disorders (amenorrhea) and can be less fertile. Breasts can develop in men.

  • Drowsiness and sleepiness

    You have a drowsy, sleepy and listless feeling. As a result, you are unable to concentrate. It is also difficult to motivate yourself to exercise, which can cause weight gain.

Pipamperon (PIP)

This is an old drug that has been researched less extensively. This means that there is a chance that it has more side effects than listed here.

  • Drowsiness and sleepiness

    You have a drowsy, sleepy and listless feeling. As a result, you are unable to concentrate. It is also difficult to motivate yourself to exercise, which can cause weight gain.

  • Low blood pressure

    When you stand up from a sitting or lying position, your blood pressure drops. This can make you feel dizzy or nauseous and you may see black spots or stars. You also have more risk of falling.

  • Sexual problems

    You have a low sex drive. For men it is more difficult to get an erection and they have less or no sperm. For women it is harder to have an orgasm. Their menstruation is irregular or absent. These symptoms may be related to the hormone prolactin, but it can also be caused by other factors.

Quetiapine (QUE)

When you use this medicine, you will sometimes need extra checkups to check on the occurrence of drowsiness and sleepiness.

  • Weight gain

    The medication makes you gain weight, because you no longer feel when you have had enough to eat. Sometimes you can even develop obesity.

  • Drowsiness and sleepiness

    You have a drowsy, sleepy and listless feeling. As a result, you are unable to concentrate. It is also difficult to motivate yourself to exercise, which can cause weight gain.

  • Dizziness

    You get dizzy when you get up from bed or a chair. This side effect usually disappears within a few days to weeks.

Risperidon (RIS)

If you use this medicine, you will sometimes need extra blood tests to measure the prolactin level.

  • Sexual problems

    You have a low sex drive. For men it is more difficult to get an erection and they have less or no sperm. For women it is harder to have an orgasm. Their menstruation is irregular or absent. These symptoms may be related to the hormone prolactin, but it can also be caused by other factors.

  • Increased prolactin level

    Your brain produces too much of the hormone prolactin. This causes sensitive breast tissue and milk discharge from your breasts. This is called galactorrhea and can occur in both women and men. You also have a low sex drive and you can gain weight. Women suffer from menstrual disorders (amenorrhea) and can be less fertile. Breasts can develop in men.

  • Stiffness of the muscles and trembling

    You have stiff muscles and difficulty with moving, walking or speaking. You may also experience tremors.

Sertindol (SER)

If you use this medicine, electrocardiograms should be made regularly.

  • Low blood pressure

    When you stand up from a sitting or lying position, your blood pressure drops. This can make you feel dizzy or nauseous and you may see black spots or stars. You also have more risk of falling.

  • ECG alterations (heart rhythm changes)

    You suffer from palpitations of the heart, an irregular heartbeat or a slower or faster heartbeat. You may suddenly become dizzy or pass out for a moment.

  • The urge to move

    You feel restless and you cannot sit or stand still. For example, you constantly twitch your legs or cross and uncross your legs.

Sulpiride (SUL)

No Additional issues for this antipsychotic.  
  • Increased prolactin level

    Your brain produces too much of the hormone prolactin. This causes sensitive breast tissue and milk discharge from your breasts. This is called galactorrhea and can occur in both women and men. You also have a low sex drive and you can gain weight. Women suffer from menstrual disorders (amenorrhea) and can be less fertile. Breasts can develop in men.

  • Sexual problems

    You have a low sex drive. For men it is more difficult to get an erection and they have less or no sperm. For women it is harder to have an orgasm. Their menstruation is irregular or absent. These symptoms may be related to the hormone prolactin, but it can also be caused by other factors.

Tiapride (TIA)

This is an old drug that has been researched less extensively. This means that there is a chance that it has more side effects than listed here.

  • Increased prolactin level

    Your brain produces too much of the hormone prolactin. This causes sensitive breast tissue and milk discharge from your breasts. This is called galactorrhea and can occur in both women and men. You also have a low sex drive and you can gain weight. Women suffer from menstrual disorders (amenorrhea) and can be less fertile. Breasts can develop in men.

  • Sexual problems

    You have a low sex drive. For men it is more difficult to get an erection and they have less or no sperm. For women it is harder to have an orgasm. Their menstruation is irregular or absent. These symptoms may be related to the hormone prolactin, but it can also be caused by other factors.

  • Drowsiness and sleepiness

    You have a drowsy, sleepy and listless feeling. As a result, you are unable to concentrate. It is also difficult to motivate yourself to exercise, which can cause weight gain.

Zuclopentixol (ZUC)

This is an old drug that has been researched less extensively. This means that there is a chance that it has more side effects than listed here.

  • Sexual problems

    You have a low sex drive. For men it is more difficult to get an erection and they have less or no sperm. For women it is harder to have an orgasm. Their menstruation is irregular or absent. These symptoms may be related to the hormone prolactin, but it can also be caused by other factors.

  • Increased prolactin level

    Your brain produces too much of the hormone prolactin. This causes sensitive breast tissue and milk discharge from your breasts. This is called galactorrhea and can occur in both women and men. You also have a low sex drive and you can gain weight. Women suffer from menstrual disorders (amenorrhea) and can be less fertile. Breasts can develop in men.

  • Stiffness of the muscles and trembling

    You have stiff muscles and difficulty with moving, walking or speaking. You may also experience tremors.

All side-effects

What are side effects?

You will be given antipsychotics to feel better. However, these drugs frequently cause new symptoms. Those are called side effects. Some side effects are minor, others have a greater impact on your life.

It will take a few weeks before you know whether the antipsychotic helps. Unfortunately, the side effects will set in immediately. However, side effects also may disappear after a while. Discuss your symptoms and concerns with your doctor, so that together you can search for a solution.

  • Amisulpride (AMI)
  • Aripiprazol (ARI)
  • Brexpiprazol (BRE)
  • Broomperidol (BRO)
  • Cariprazine (CAR)
  • Chloorprotixeen (CHL)
  • Clozapine (CLO)
  • Flupentixol (FLP)
  • Fluspirileen (FLS)
  • Haloperidol (HAL)
  • Lurasidon (LUR)
  • Olanzapine (OLA)
  • Paliperidon (PAL)
  • Penfluridol (PEN)
  • Periciazine (PER)
  • Pimozide (PIM)
  • Pipamperon (PIP)
  • Quetiapine (QUE)
  • Risperidon (RIS)
  • Sertindol (SER)
  • Sulpiride (SUL)
  • Tiapride (TIA)
  • Zuclopentixol (ZUC)
  • High : affects more than 30 in 100 people
  • Moderate : affects 10 to 30 in 100 people
  • Low : affects 1 to 10 in 100 people
  • Very low : affects less than 1 in 100 people
  • No side effects
  • AMI ARI BRE BRO CAR CHL CLO FLP FLS HAL LUR OLA PAL PEN PER PIM PIP QUE RIS SER SUL TIA ZUC

What are side effects?

You will be given antipsychotics to feel better. However, these drugs frequently cause new symptoms. Those are called side effects. Some side effects are minor, others have a greater impact on your life.

It will take a few weeks before you know whether the antipsychotic helps. Unfortunately, the side effects will set in immediately. However, side effects also may disappear after a while. Discuss your symptoms and concerns with your doctor, so that together you can search for a solution.